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Regulatory frameworks require detailed impurity profiling (0.10%) and stability-indicating assays, making LC-MS an essential tool in GLP-1 drug development and quality control

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b) Clinical studies (NEJM, The Lancet Diabetes & Endocrinology) report cardiovascular and metabolic improvements beyond sugar control

In December 2023, the European Commission restricted the use of two of the most widely used SPPS solvents, DMF 4 and NMP 5 , due to their reproductive toxicity

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