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In terms of effectiveness, GLP-1s outperform most other options

These side effects are generally mild and will subside on their own without the need for medical intervention

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Clegg LE, Heerspink HJL, Penland RC, et al

Work published in Science Advances in 2025 found that GLP-1 acts on GABA neurons in the VTA to suppress dopamine signaling, functioning as a brake on the reward system [4]