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Practical management considerations include: Dose review: If the heart rate increase is dose-dependent and symptomatic, reducing the dose or slowing the titration schedule where permitted by the trial protocol may help mitigate the effect whilst preserving therapeutic benefit
Document why each was discontinued (inadequate control, side effects, etc.)
A limitation with the use of GLUTag cells, as well as other models for epithelial cells, is that the cells have lost their polarization, which may affect the amino acid sensing mechanisms, as different amino acid transporters are situated on the apical compared to the basolateral membrane [28]
MPNSTs often appear as large, heterogeneously enhancing, and poorly defined soft-tissue masses on MRI
Wojcicki JM, Holbrook K, Lustig RH, Caughey AB, Munoz RF, Heyman MB: Infant formula, tea, and water supplementation of Latino infants at 4-6 weeks postpartum
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