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GLP-1 agonists are a synthetic version of the bodys naturally occurring GLP-1
The manufacturer's labeling clearly warns against freezing and advises discarding any semaglutide that has been frozen, even if it subsequently thaws and appears normal
Whereas GLP-1 (7-36) amide stimulates glucose-dependent insulin secretion and inhibits glucagon secretion, GLP-1(9-36) amide administration had no effect on glucose clearance or insulin secretion in humans
Some GLP-1 analogs use recombinant fermentation processes
Otherwise it risks spinning out of control
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