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Metformin should be taken with meals to help reduce stomach or bowel side effects that may occur during the first few weeks of treatment

doi:10.1038/s41572-025-00603-8

Side effects with Wegovy 7.2 mg The STEP UP trial found that side effects were somewhat more common at the 7.2 mg dose than at 2.4 mg: 2 GI side effects: 70.8% (7.2 mg) vs 61.2% (2.4 mg) Dysaesthesia (tingling or numbness): 22.9% (7.2 mg) vs 6.0% (2.4 mg) Discontinuation due to side effects remained low at 3.3% The dysaesthesia finding is notable, though 85.7% of cases resolved while continuing treatment