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Therapeutic dosing of 1 to 2 g/day typically results in plasma concentrations of 1 to 40 M [7,23], whereas hepatic concentrations are estimated to be two- to three-fold higher, reflecting both firstpass exposure and high transporter expression [29,30]
Glia 43 , 3743 (2003)
If the patient doesn't work to rebuild that lean mass, Ahmed says, that could lead to sarcopenia muscle loss which adversely affects balance, movement, metabolism and can lead to broken or weakened bones
10.18632/oncotarget.4052 62 HaugenB
Notably, 10 cases (25.6%) involved an escalation in drug dosage within 3 months preceding the event
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