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Indeed, gut bacteria play a central role in this metabolic framework by expressing BSH and downstream enzymes that deconjugate primary bile acids (synthesized from cholesterol in the liver) and transform them into secondary bile acids, profoundly modifying their physicochemical properties, intestinal reabsorption, and receptor signaling (80)

For example, high-fat feeding alters the small intestinal microbiota to increase intestinal, brain, and circulatory levels of taurine-conjugated bile acids, including and taurochenodeoxycholic acid (TCDCA), which is an FXR agonist 272

This is where errors creep in, because researchers get comfortable drawing the same amount week after week and then forget to adjust when the escalation hits

Some patients roll the pen gently between their palms for 30 seconds to accelerate temperature equilibration without exposing it to direct heat

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