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In the absence of oxygen, N-oxides can be converted into corresponding amines after binding with heme iron of various cytochrome P450 enzymes (CYP450), and irreversible two-electron reduction occurs
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Mitochondrial dysfunction, apoptosis and oxidative stress are in part due to methylglyoxal accumulation
What makes these two conditions so prevalent yet so difficult to diagnose
For example, if you're using your abdomen, you could think of it like a clock and move to a different 'hour' each week
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