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Elevated levels of MTA and SAMe are tightly linked to T-cell exhaustion in hepatocellular carcinoma (HCC), and deletion of a key SAMe-producing enzyme MAT2A results in inhibition of T-cell exhaustion and limitation of HCC growth in mice (86)
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Klein BE, Klein R, Lee KE
Lyme disease is often persistent and complextriggering chronic fatigue, joint pain, cognitive fog, and co-infections
Keytruda (pembrolizumab), Mercks blockbuster cancer immunotherapy, faces patent expirations beginning in 2028 that will trigger one of the largest biosimilar development races in pharmaceutical history [52]
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