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Although studies have shown that FOXO4-DRI can block the binding of P53 to FOXO4, thereby promoting the apoptosis of senescent cells, the effect of FOXO4-DRI is not limited to alleviating the aging of certain organs

The cytosolic subunits need to be phosphorylated by kinases like PKC in order to be recruited to the surface membrane (Schrder et al., 2017) (Figure 1)

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1997 Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53 EMBO J