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Doxorubicin resistant cells showed significantly increased RNA expression of anaplerotic genes pyruvate carboxylase, malic enzyme 1 (ME1), and malic enzyme 2 (ME2), corroborated by the enrichment of TCA cycle intermediates citrate, malate, and fumarate (Kim, 2018)

David Sinclair notes in his work: "NAD+ is pivotal for sirtuins and aging reversal

1 Several preclinical investigations have associated the activation of IGF-1R by its two natural ligands, insulin-like growth factor-1 (IGF-1) and IGF-2, 2 as primary risk factors in various types of human diseases 3 including cancer

The treatment includes 500 mg NAD and a minimum of 500 milligrams of Normal Saline