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The GLP-1R/GIPR dual-agonist tirzepatide has demonstrated a remarkable 23% body weight reduction in individuals with obesity over 72 weeks, eclipsing the average result achieved by certain bariatric surgery [78]
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doi: 10.1007/s12016-015-8525-4 37 ArduiniARossiMMancinelliGBelfiglioMScurtiRRadattiGet al
In contrast, subchronic oral application of CoQ10 (100 mg/kg or more) enhanced time latencies to the onset of myoclonic jerks and clonic seizures induced by intraperitoneal pentylenetetrazole (PTZ) and at the doses of 25 mg/kg or more augmented the seizure threshold provoked by intravenous injection of PTZ
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