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From the clinical perspective, the advantage of this finding is that diabetics can receive a treatment based on activation of GLP-1R targeting their diabetes (i.e., antihyperglycemic), as well as improving the prognosis of stroke
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Finally, TRANSCEND-T2D-3 (NCT06297603) will compare retatrutide to placebo over 14 months, in people with inadequately controlled T2D and moderate-or-severe renal impairment on basal insulin
Sources: Veniant et al., Nat Metab, 2024
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