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Which GLP-1 Drug is Most Effective for Weight Loss
Tirzepatide, a dual GLP-1/GIP agonist, shows slightly higher average loss (2022%), but semaglutide remains a powerful first-line choice for most people
2017;26(2):34352 e2
WHY USE
The observable consequence is the most potent weight- and glucose-lowering profile of any molecule approved before retatrutide: SURMOUNT-1 reported roughly 22.5% weight reduction at the 15 mg dose over 72 weeks 13, and SURMOUNT-5 showed tirzepatide superior to semaglutide 2.4 mg head-to-head at 72 weeks (20.2% vs 13.7%) 18
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