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A 26-week diabetes study measured human activity at 1 mg, but its endpoint was blood sugar rather than long-term weight. A short outpatient cohort measured about 4.7% weight loss over four weeks at 2.5 mg. Below 1 mg, estimates rely on pharmacokinetics and mechanism

This leaves the hair follicles vulnerable to oxidative damage and pigment loss

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We need to recognise that this will also apply to animal patients

This means that the ingredients work directly on the area where the lotion is applied