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The smaller size is a more comfortable quantity of liquid injecting into your muscles, thus providing less soreness, but it also leaves room to add a sterile water solution or other vitamins

11 Its also important to note that taking B12 in combination with vitamin B6 and folate (rather than alone) is shown to be most effective for regulating homocysteine levels for some patients and preventing the combined risk of stroke, myocardial infarction (heart attack), and damage to heart cells

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This happens because they share the same risk factors