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Available data are insufficient to inform recommendations to mitigate the risk of pulmonary aspiration during general anesthesia or deep sedation in patients taking WEGOVY, including whether modifying preoperative fasting recommendations or temporarily discontinuing WEGOVY could reduce the incidence of retained gastric contents

Switching from semaglutide to tirzepatide dosing typically involves starting tirzepatide at the initial recommended dose (e.g., 2.5 mg) regardless of the prior semaglutide dose, to assess tolerance and minimize gastrointestinal side effects

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