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Key Drivers of Insulin Resistance: Excess Adiposity Visceral and liver fat impair insulin signaling Chronic Inflammation Pro-inflammatory cytokines (TNF-, IL-6) disrupt insulin pathways High Circulating Free Fatty Acids (FFA) Excess fat in non-adipose tissues causes insulin resistance Mitochondrial Dysfunction Impaired cellular energy metabolism reduces insulin effectiveness The Problem: While this model explains many cases of hyperinsulinemia, it doesnt fully account for individuals who develop insulin resistance after prolonged insulin hypersecretion
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Hainaut P, Wiman KG
The renewal of the gastric epithelium is ensured by stem cells located within the tubular glands 48 , where a subpopulation of fundic chief cells, expressing Lgr5, has been identified and can function as injury-responsive reserve stem cells 49
