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Studied in research involving extracellular matrix remodeling, collagen synthesis, and metalloproteinase signaling

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examined the effectiveness of a Japanese oral supplement containing collagen peptides on skin hydration and the natural moisturizing factor content in 99 healthy Japanese women, aged 3550 years, who were divided into three groups (33 subjects/group) and received 1 or 5 g of collagen peptides or placebo once daily for 12 weeks [38]