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A slight elevation in the level of LPO was recorded in group 3 with respect to the control, whereas, a gradual decline in the level of LPO was noted in groups 1 to 2 (Figure 3A)
However, the systemic introduction of ARA-290 in OIR mice seemed to lower the levels of pro-inflammatory cytokines like IL-1 and TNF- in the retinal tissue, hinting at its possible anti-inflammatory properties
In particular, our nascent transcriptome analyses showed a significant increase in SLC7A11 gene transcription in both C1-27 - and GSTO1 siRNA-treated cells
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