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NO is involved in normal cell signaling, contributing to the regulation of various physiological functions [141, 142] including activation of soluble guanylyl cyclase (sGC) which generates cyclic GMP (cGMP) [143]

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doi:10.17179/excli2020-2763 113

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Exclusion criteria: Clinical trials

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Explain how the skin reactions affect your daily life and whether they seem to be getting better or worse

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All five treatment groups had reductions in absolute body weight and BMI at 24 weeks, but the exenatide and dapagliflozin group had greater weight loss than those receiving only dapagliflozin or dapagliflozin and metformin ( P = .005)

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