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Previous studies have reported that GPX4 genetic deficiency leads to nephrotoxic effects [19], and its role in ischemia/reperfusion-induced acute kidney injury and obstructive renal fibrosis is well-documented [14, 38]

The above results reveal that excessive zinc activates the ISR with elevated ATF4 expression in SC- cells

Our approach is personal, not one-size-fits-all

Glycinamide, a small -MSH-mimicking peptide blocking MC1R receptor, inhibited melanin synthesis in melanocytes and reduced skin pigmentation in volunteers after topical application [117]

The derived data supporting the findings of this study are available from the corresponding author upon request