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Dopaminergic afferents from the ventral tegmental area (VTA) in the midbrain project largely to the NAc (mesolimbic pathway), while the substantia nigra (SN) pars compacta is the main source of dopamine in the dorsal striatum (nigrostriatal pathway)
doi: 10.1371/journal.pone.0067578 100 FarahLXValentiniVPessoaTDMalnicGMcDonoughAAGirardiAC
These cardiovascular characterisation studies established that MT-IIs haemodynamic effects are mechanistically related to its central MC3R/MC4R activation rather than to peripheral melanocortin receptor engagement
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