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The far-right column shows the total expenditures for each year, starting at only $188.3 million in 2012 and skyrocketing to $13.91 billion by 2022, an increase of an unbelievable 7,921 percent

First, this analysis was based on aggregated arm-level data rather than individual participant data, which limited the ability to adjust for patient-level heterogeneity, including comorbidities and concomitant therapies

[27] Canagliflozin is the first SGLT2 inhibitor to be approved for use in the United States

An identical study undertaken across 6 countries evaluated the tolerability of GLP-1 agonists in pregnant women and their effects on fetal outcomes (91)

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