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Diarrhea is a well-documented and relatively common adverse effect of semaglutide therapy

[2] The safety profile of Orforglipron was consistent with existing GLP-1 therapies, with the most common adverse events being mild to moderate gastrointestinal symptoms such as diarrhea, nausea, dyspepsia, and constipation

Weight-bearing exercise and strength training help protect bone density during weight loss

In Phase 2 trials, retatrutide achieved up to 82% reduction in liver fat, a number that caught hepatologists by surprise

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