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Variable importance of projection (VIP) values obtained from the OPLS-DA model was used to rank the overall contribution of each variable to group discrimination

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The addition of GIP activation in tirzepatide may provide additive metabolic and weight-loss effects, though individual response varies significantly based on genetics, baseline physiology, and lifestyle factors

Over the 8 residues spanning P4 to P4, it has 7 of 8 identical to the M pro site at the nsp12/nsp13 junction, with the only mismatch at the highly variable P3 position (Figure 1D), giving a near-perfect match to the M pro consensus