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Prednisone Interactions and Contraindications Interactions: Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): The concurrent use of NSAIDs and prednisone increases the risk of gastrointestinal ulcers and bleeding

Curr Opin Microbiol (2001) 4(1):416

Researchers with the ongoing, multinational Semaglutide Effects on Cardiovascular Outcomes in Patients With Overweight or Obesity (SELECT) trial randomly assigned 17,604 participants aged 45 years or older who were overweight or obese and had cardiovascular disease but not diabetes to receive a weekly injection of 2.4 milligrams of semaglutide or a placebo

The principle is the same for both: start low, increase slowly, let your body adapt

In fact, it's the only weight loss injection licensed for both weight management and cardiovascular risk reduction