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Pathogenic variants in the MMACHC, MMADHC, LMBRD1, ABCD4, or HCFC1 genes all affect the early steps in the overall processes of converting cobalamin to its co-enzyme forms, AdoCbl and MeCbl leading to deficiencies in both of these important cofactors
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76 Specifically, n-6 PUFAs promote immune suppression by shifting DC metabolism toward glycolysis, thereby reducing immune stimulation
Frequency: 3 times daily for 20-week cycles
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