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DCCT sub-analyses established that glycemic variability (not just HbA1c) predicts diabetic complication risk, making pramlintide's variability-reducing effects potentially more clinically important than the modest HbA1c change alone

PMID: 33413467

Elevated GH and IGF-1 can support follicular development and steroidogenesis, potentially increasing progesterone and estradiol levels that support implantation and early pregnancy

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