So depending on other cardiovascular risk factors (high cholesterol, high sugar, diabetes and others), the medical risk may outweigh the benefits of using hormonal combined methods
The cumulative effect builds over 2 to 4 weeks of consistent injections, which is why Triny typically recommends a loading phase before transitioning to monthly maintenance
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It kind of weakened the results
Adverse effects observed in trials to date include: Gastrointestinal symptoms nausea, vomiting, diarrhoea, and constipation (common with GLP-1 receptor agonists) Reduced appetite and weight loss , which may be excessive in some individuals Elevated heart rate , a concern noted with glucagon receptor agonism As with other incretin-based therapies, there is also a class-level signal for acute pancreatitis and gallbladder disease (including cholelithiasis and cholecystitis)