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The enteric nervous system and central nervous system are functionally interdependent
The stack produces faster early improvement than microneedling alone, particularly in the first three weeks
Availability of data and materials N/A Abbreviations ALCAR: Acetyl-L-carnitine ANG: Angiogenin BPH: Benign prostatic hyperplasia CCL2: C-C Motif Chemokine Ligand 2 CCR2: C-C chemokine receptor type 2 CM: Conditioned media CXCL12: C-X-C Motif Chemokine Ligand 12 CXCL8: C-X-C Motif Chemokine Ligand 12 CXCR1: C-X-C chemokine receptor type 1 CXCR2: C-X-C chemokine receptor type 2 CXCR4: C-X-C chemokine receptor type 4 DAPI: 4,6-diamidino-2-phenylindole EBM: Endothelial basal medium EGM: Endothelial growth medium FACS: Fluorescence activated cell sorting FBS: Foetal bovine serum FC: Flow cytometry FSC: Forward-scattered light ICAM-1: Intercellular adhesion molecule 1 IL-6: Interleukin-6 MCP-1: Monocyte chemoattractant protein 1 NFB: Nuclear factor kappa-light-chain-enhancer of activated B cells PBMCs: Peripheral blood mononuclear cells PCa: Prostate cancer SDF-1: Stem-derived facrior-1 SSC: Side-scattered light VEGF: Vascular endothelial growth factor VEGFR: Vascular endothelial growth factor receptor References Jaiswal S, Sarmad R, Arora S, Dasaraju R, Sarmad K
Laboratory findings indicate the peptide may help maintain stem cell function, though more specific research continues in this area
Effects were seen at extremely low concentrations (10 -12 to 10 -9 M), but higher concentrations actually inhibited growth demonstrating a precise dose-response relationship
