Under homeostatic conditions, transient activation of NRF2 is cytoprotective, allowing for adaptation to various cell intrinsic (i.e., reactive oxygen species (ROS) generated by mitochondrial function) and extrinsic (i.e., xenobiotic) stressors (Kensler et al, 2007
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While further studies are needed to establish definitive connections, the antioxidant and detoxification properties of glutathione suggest it may play a supportive role in these contexts
I wanted to understand what was happening at the cellular level
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