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Lancet 407 , 21672179 (2026)

[] FXR activation simultaneously drives energy consumption in brown adipose tissue and skeletal muscle while transcriptionally up-regulating TGR5

There are myriad causes for cramps, and each may call for different specific measures, even medication, as when restless leg syndrome is addressed with drugs ordinarily used for Parkinsons Disease, or when multiple sclerosis sufferers receive powerful muscle relaxants

These symptoms typically occur during the initial weeks of treatment and often improve as the body adjusts to the medication

Values are provided as published reference figures for research identification