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Though the body can produce L-citrulline naturally, supplementation provides additional benefits, especially for athletes and active individuals seeking to enhance their results

Additional support of this work was from Canadian Institutes of Health Research Project Grant DOL 409157 (to J.R.), and by Natural Sciences and Engineering Research Council of Canada Research Tools and Instrumentation Grant 2018-00846 (to J.R.)

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Moreover, a study comparing the fetal metabolome of specific pathogen-free (SPF) and GF mice demonstrated drastic differences among metabolites known to harbor immunological potential [26]