Telomere shortening to a critically short length leads to epigenetic defects at mammalian telomeres and subtelomeres, characterized by decreased histone and DNA methylation and increased histone acetylation
The anti-cancer properties of biguanides are displayed through several mechanisms of action, including the activation AMPK pathway with the consequent inhibition of mTOR and reduction of several pro-tumorigenic effects including cell proliferation and production of inflammatory mediators (Seyfried et al., 2014
Repair & Glow is a three-peptide protocol combining BPC-157, TB-500, and GHK-Cu to support tissue recovery and collagen production simultaneously
MacFie J, Reddy BS, Gatt M, et al
The REWIND trial with dulaglutide included many patients without established ASCVD and demonstrated a consistent reduction in MACE, supporting a role in primary prevention, although the effect size was modest