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This metabolic shift rapidly depletes cellular glycogen reserves, generates excessive lactic acid, and leads to the crushing, unyielding fatigue that characterizes the Long COVID experience

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Abbreviations NPs: Nanoparticles CRISPR: Clustered regularly interspaced short palindromic repeats CAR: Chimeric antigen receptor PNPs: Polymeric NPs PEG: Polyethylene glycol PLGA: Poly(lactic-co-glycolic acid) pDNA: Plasmid DNA LNP: Lipid NPs AuNPs: Gold NPs GQDs: Graphene quantum dots AgNPs: Silver NPs MSNs: Mesoporous silica NPs TLRs: Toll-like receptors LDH: Layered double hydroxide EVs: Extracellular vesicles mRNA: Messenger RNAs siRNAs: Small interfering RNAs miRNAs: MicroRNAs ASOs: Antisense oligonucleotides Cas9: CRISPR-associated protein 9 AAV: Adeno-associated virus AI: Artificial intelligence AGILE: AI-Guided Ionizable Lipid Engineering TME: Tumor microenvironment CS: Chondroitin sulfate TNBC: Triple-negative breast cancer BBB: Blood-brain barrier RMT: Receptor-mediated transcytosis Tf: Transferrin RVG: Glycoprotein nAchR: Nicotinic acetylcholine receptor Plofsomes: Polymer-locked fusogenic liposomes GBM: Glioblastoma multiforme ApoE: Apolipoprotein E3-reconstituted high-density lipoprotein siPKM2: Pyruvate kinase M2 siRNA MDM2: Mouse double minute 2 NIR: Near-infrared radiation sgRNA: Single-guide RNA DSB: Double-strand break NHEJ: Non-homologous end-joining HDR: Homology-directed repair ROS: Reactive oxygen species SPs: Semiconducting polymers SORT: selective organ targeting RNP: Cas9/gRNA ribonucleoprotein complex OMVs: Outer membrane vesicles TCR: T cell receptor IL: Interleukin STING: Stimulator of interferon genes References Ledley FD

For consistent tracking, use the same laboratory and the same kit for all measurements

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