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Other flagged risks include: Pancreatitis Gallbladder disease Possible worsening of diabetic retinopathy in people with diabetes Rare reports of suicidal thoughts Rodent studies showed an increased risk of medullary thyroid tumors, so semaglutide is contraindicated for people with a personal or family history of medullary thyroid carcinoma or MEN2 syndrome
Rojas, M
Similarly, PDE3 inhibitors such as milrinone and cilostazol demonstrate cardiovascular adverse effects, including arrhythmias, tachycardia, and palpitations, attributable to PDE3 expression in myocardium and vascular smooth muscle (Kuzmiszyn et al., 2022)
Additionally, the safety and tolerability profiles of GLP-1RAs have been well-established
Role of endolysosomes in severe acute respiratory syndrome Coronavirus-2 infection and coronavirus disease 2019 pathogenesis: implications for potential treatments
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