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Activation of both GIP and GLP-1 receptors by retatrutide probably contributed to the observed changes in circulating triglycerides, as treatment with the dual GIP/GLP-1 receptor agonist tirzepatide significantly reduced triglyceride levels by up to 29% at 52 weeks in a clinical trial in people with T2D and MASLD 8
Kidney Int 2020;98:57989.PubMedPMC 26
Fasting glucose drops, insulin levels normalize, and the body becomes more responsive to endogenous insulin signaling
Unfortunately, those concerns about weight regain are legitimate
When you combine the appetite suppression of a GLP-1 with the high-intensity demands of HYROX or DEKA training, you create a metabolic "clash" that can stall your progress and break your body down
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