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Notably, the age-related increases in nitration of ECM-bound HGF were predominant on fast IIa and IIx myofibers 32 , corresponding with the fast fiber-preference observed in age-related muscle atrophy and impaired regeneration in humans in which fast IIb fibers are scarce 33,34,35, 39

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7,9 The emergence and expansion of resistant clones are often driven by Darwinian evolutionary principles, whereby treatment selectively eliminates sensitive populations while allowing drug-tolerant persister (DTP) cells or preexisting resistant subclones to dominate

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