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Well, they probably don't
However, alcohol disrupts sleep architecture (particularly REM sleep), impairs melatonin production, and increases cortisol, essentially working against everything pineal peptides are trying to achieve
A Phase 1b study first established that co-administering cagrilintide with semaglutide 2.4 mg was tolerable and characterized cagrilintides pharmacokinetics, including its multi-day half-life of roughly 159195 hours
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