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25 Thus, while autophagy is clearly protective under physiological and early stress conditions, its chronic hyperactivation may become maladaptive

This scoring system allowed for semi-quantitative evaluation of cartilage integrity based on macroscopic features such as softening, fibrillation, erosion, ulceration, and complete cartilage loss [1]

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Conversely, ultra-conservative approaches increase every 4-6 weeks

Oral corticosteroids (prednisone) provide short-term anti-inflammatory benefit but have significant side effect profiles with repeated courses, including bone density loss, immune suppression, and metabolic disruption