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Future Research Directions and Unanswered Questions Despite 50+ years since Pickarts initial isolation work, significant mechanistic and clinical questions remain: Receptor identity: GHK-Cus gene regulatory effects are well-documented, but the specific cellular receptors mediating them remain incompletely characterized
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Once reconstituted, storage conditions significantly affect stability, and researchers should consult peptide storage guidelines to ensure proper handling
Inconsistent administration Skipping doses, irregular timing, and forgotten applications all reduce effectiveness
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