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Furthermore, systematic reviews and meta-analyses of cardiovascular outcome trials (CVOTs)involving over 60,000 patientsdemonstrate that these agents reduce major adverse cardiovascular events (MACE) by 1214% [49]
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TB-500 and KPV likewise rest on animal and cell research for migration/repair and anti-inflammatory activity respectively mechanistically plausible, but not validated in humans as part of this blend
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These effects are also seen in patients with T2DM and in other insulin-resistant states such as obesity [135, 136] and may be mediated in part by restoration of vascular insulin sensitivity [137]
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