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Its androgenic effects are like exogenous androgens thereby causing decreases in FSH and LH secretion which can negatively impact sperm production
The risks rise even further the longer the gap, with up to 22% higher risk of a major cardiovascular event after two years off therapy
At the same time, GLP-1 receptor agonists are being prescribed with increasing frequency for metabolic indications, including in patients with IBD
J Gen Physiol 110(3):217228
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