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AOD 9604 is one specific blade from that knife, doing one job extremely well without the complications

AOD9604 and Safety Pharmacology Research A conventional Ames test showed no significant mutation rate increase for AOD9604 at up to 2,000 g/plate, with no clastogenic effects observed in CHO-cell chromosome aberration assays

Heffernan M et al

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Confirming the deficiency with a blood test is what makes that trade-off clear