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Longer-term liraglutide administration at the highest dose approved for obesity increases reward-related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti-obesity therapies

And success

Insulin Secretion and Sensitivity Apart from stimulating insulin release, GLP-1 suppresses the secretion of glucagon, a hormone that increases blood glucose levels by promoting gluconeogenesis and glycogenolysis in the liver

That effect belongs to GLP-1 medications like semaglutide and tirzepatide

Unlike retraglutide, which targets three receptors, semaglutide only targets one-the GLP-1 receptor