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Pattern 2: The Non-Responder (approximately 15% of switchers) Weight loss plateaus or slows despite escalating to Zepbound 12.5 to 15 mg May report initial response at 5 to 7.5 mg that fades by week 16 to 20 Often have underlying metabolic factors (severe insulin resistance, hypothyroidism, medications causing weight gain) For this group, the switch to tirzepatide does not solve the core problem

It is distinguished by its selectivity

Heller RS, Kieffer TJ, and Habener JF

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There is increasing understanding of the complexity of how genes regulate functions of stem cells [ 8 ]