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Cardiovascular safety DPP-4 inhibitors provide no benefits above the standard of care for people with established or high risk of atherosclerotic cardiovascular disease, heart failure or chronic kidney disease
Vulliamy, T
More recently, the FLOW study, which focused on evaluating the nephroprotective and cardioprotective efficacy of semaglutide, a GLP-1RA, in patients with T2DM and CKD (N = 3534), was stopped prematurely as it met certain pre-specified efficacy criteria, with a very high likelihood of study success on reducing the progression of renal disease [61]
GLP-1 medications alone don't inherently teach patients how to eat for their goals or build sustainable habits and these findings suggest that digital self-monitoring may help address that gap
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