Patients who expect universal 20%+ weight loss within three months often discontinue prematurely when their trajectory differs
Compared to cognitively normal older adults, cerebrovascular resistance is higher in individuals with MCI and ADRD, and has been associated with greater A burden, cortical atrophy, and risk of progression to ADRD (Yew and Nation, 2017)
Since the mean/median duration for each of these studies was 100,000 patients prescribed a GLP-1RA, after propensity matching, there was reduced risk for PDAC during a 5-year observation period for GLP-1RA users compared to six categories of commonly used diabetes medication classes 44
Alternatives May Be Worth Exploring If You: Prefer FDA-approved branded medications: Compounded GLP-1 medications are not FDA-approved finished products
Patients pursuing any of these options should do so under physician supervision