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Both ipamorelin and semorelin are medications that are made to duplicate the action of the naturally occurring GHRH, Ghrelin
The METAOD006 (OPTIONS) oral Phase 2b trial measured weight at 12 and 24 weeks
Lactate production and glucose consumption were normalized to cell numbers
This supports redox homeostasis and lipid synthesis, along with providing -ketoglutarate which can regulate epigenetics or be used as a backbone for glutamate and glutamine synthesis (98100)
doi:10.1016/j.bbagen.2012.09.008
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